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In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.Since memories are postulated to be represented by vastly interconnected networks of synapses in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory).

If more of the same type of postsynaptic receptors are activated, then more Na will enter the postsynaptic membrane and depolarize cell.

The Hodgkin–Huxley model of an action potential in the squid giant axon has been the basis for much of the current understanding of the ionic bases of action potentials.

Briefly, the model states that the generation of an action potential is determined by two ions: Na and K .

There are two families of receptors: ionotropic and metabotropic receptors.

Ionotropic receptors are a combination of a receptor and an ion channel.

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